Yes. A driver of a vehicle with an actual gross weight, gross vehicle weight rating (GVWR) or Gross combination weight rating (GCWR) of 10,001 or more pounds; a vehicle designed to transport 9 or more passengers, including the driver, for compensation or a vehicle designed to transport 15 or more passengers, including the driver, not for compensation; or a vehicle used to transport hazardous materials requiring placarding; used in intrastate or interstate commerce, must pass a medical examination and carry a medical examiner's certificate.